90钇微球动脉内放射治疗引起的纤维化、门静脉高压和肝脏体积变化。
Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90yttrium microspheres.
作者信息
Jakobs T F, Saleem S, Atassi B, Reda E, Lewandowski R J, Yaghmai V, Miller F, Ryu R K, Ibrahim S, Sato K T, Kulik L M, Mulcahy M F, Omary R, Murthy R, Reiser M F, Salem R
机构信息
Department of Radiology, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Marchioninistrasse 15, Munich, Germany.
出版信息
Dig Dis Sci. 2008 Sep;53(9):2556-63. doi: 10.1007/s10620-007-0148-z. Epub 2008 Jan 31.
PURPOSE
To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver.
RESULTS
In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities.
CONCLUSION
(90)Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.
目的
确定肝转移瘤患者经玻璃微球放射性栓塞术后肝实质体积、纤维化及门静脉高压的诱导变化。
结果
在我们一系列连续的双侧叶（n = 17）治疗中，肝脏体积平均减少11.8%。在该组中，脾脏体积平均增加27.9%，门静脉直径增加4.8%。对于接受单侧叶治疗的患者（n = 15），同侧叶体积平均减少8.9%，对侧叶肥大21.2%，门静脉直径增加5.4%。这些发现与临床毒性无关。
结论
利用玻璃微球对肝转移瘤患者进行钇-90放射性栓塞可导致肝实质体积变化，并引发提示纤维化和门静脉高压的表现。有必要进一步开展评估长期影响的研究。
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