内嗅皮层损毁后大鼠学习与记忆提取过程中海马中某些微量元素和常量元素含量的变化

Variations in the content of some trace elements and macroelements in the hippocampus of rats during learning and memory retrieval after destruction of the entorhinal cortex.

作者信息

Gigineishvili Ts V, Gegenava L G, Machavariani N A, Magradze N M

机构信息

I. S. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi.

出版信息

Bull Exp Biol Med. 2007 Jun;143(6):667-9. doi: 10.1007/s10517-007-0209-5.

DOI:10.1007/s10517-007-0209-5

PMID:18239796

Abstract

We studied variations in the concentration of Na, K, Ca, and Mg in the hippocampus of rats with damaged entorhinal cortex. The concentration of Mg, Na, K, and Ca remained practically unchanged, while the content of Zn and Cu increased during learning and memory retrieval in animals with damaged entorhinal cortex. Our results indicate that Zn and Cu, constituents of metalloproteins and metalloenzymes, play an important role in hippocampal function.

摘要

我们研究了内嗅皮质受损大鼠海马中钠、钾、钙和镁浓度的变化。镁、钠、钾和钙的浓度基本保持不变，而在内嗅皮质受损动物的学习和记忆恢复过程中，锌和铜的含量增加。我们的结果表明，作为金属蛋白和金属酶成分的锌和铜在海马功能中起重要作用。