二氯（S-甲基-L-半胱氨酸）钯（II）与生物相关配体的络合反应。S供体螯合物诱导的活化作用。

Complex-formation reactions of dicholoro(S-methyl-L-cysteine)palladium(II) with bio-relevant ligands. Labilization induced by S-donor chelates.

作者信息

Shehata Mohamed R, Shoukry Mohamed M, Nasr Fatma M H, van Eldik Rudi

机构信息

Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.

出版信息

Dalton Trans. 2008 Feb 14(6):779-86. doi: 10.1039/b709332b. Epub 2007 Oct 23.

DOI:10.1039/b709332b

PMID:18239833

Abstract

The complex-formation equilibria of [Pd(SMC)(H2O)2]+, where SMC = S-methyl-l-cysteinate, with bio-relevant ligands such as amino acids, peptides, dicarboxylic acids and DNA constituents were studied and their formation constants were determined. The binding mode of the ligands containing various functional groups was studied and the speciation diagrams were evaluated. The kinetics of base hydrolysis of amino acid esters bound to [Pd(SMC)(H2O)2]+ was studied in aqueous solution at 25 degrees C and 0.1 M ionic strength. The effect of solvent polarity and temperature on the hydrolysis of coordinated glycine methyl ester was investigated. The activation parameters are evaluated and discussed.

摘要

研究了[Pd(SMC)(H₂O)₂]+（其中SMC = S-甲基-L-半胱氨酸盐）与氨基酸、肽、二羧酸和DNA成分等生物相关配体的络合形成平衡，并测定了它们的形成常数。研究了含有各种官能团的配体的结合模式，并评估了物种形成图。在25℃和0.1 M离子强度的水溶液中研究了与[Pd(SMC)(H₂O)₂]+结合的氨基酸酯的碱水解动力学。研究了溶剂极性和温度对配位甘氨酸甲酯水解的影响。评估并讨论了活化参数。