[基于日本全国性调查的氟代脱氧葡萄糖正电子发射断层显像（FDG-PET）及PET/CT癌症筛查性能概况]
[Performance profile of FDG-PET and PET/CT for cancer screening based on a Japanese nationwide survey].
作者信息
Minamimoto Ryogo, Senda Michio, Uno Kimiichi, Jinnouchi Seishi, Iinuma Takeshi, Ito Kengo, Okuyama Chio, Oguchi Kazuhiro, Kawamoto Masami, Suzuki Yutaka, Tsukamoto Eriko, Terauchi Takashi, Nakashima Rumi, Nishio Masami, Nishizawa Sadahiko, Fukuda Hiroshi, Yoshida Tsuyoshi, Inoue Tomio
机构信息
Department of Radiology, Graduate School of Medicine, Yokohama City University.
出版信息
Kaku Igaku. 2007 May;44(2):105-24.
A total of 50,558 healthy subjects underwent an FDG-PET (including PET/CT) scan with or without combination of other tests for cancer screening in 46 PET centers during fiscal year of 2005 in Japan. Thorough examination was indicated for 9.8% of the cases due to positive findings suggesting possible cancer. On analyzing 43,996 cases from 38 PET centers, where detailed information was obtained, 500 cases of cancers (1.14%) were found, of which 0.90% was PET positive and 0.24% was PET negative, resulting in the relative sensitivity of PET being 79.0%. Cancers of thyroid, colon/rectum, lung and breast were most frequently found (107, 102, 79, 35 cases, respectively) with high PET sensitivity (88%, 90%, 80%, 92%). PET showed an overall positive predictive value of 29.0%. PET/CT had better detection rate, sensitivity, and positive predictive value than dedicated PET (p<0.01).
2005财年，日本46个PET中心共有50558名健康受试者接受了FDG-PET（包括PET/CT）扫描，扫描时或联合或未联合其他癌症筛查检测。因发现提示可能患癌的阳性结果，9.8%的病例需进行全面检查。对来自38个PET中心的43996例病例进行分析（这些病例可获取详细信息），发现了500例癌症（1.14%），其中PET阳性的占0.90%，PET阴性的占0.24%，PET的相对灵敏度为79.0%。甲状腺癌、结肠/直肠癌、肺癌和乳腺癌最为常见（分别为107例、102例、79例、35例），PET灵敏度较高（分别为88%、90%、80%、92%）。PET的总体阳性预测值为29.0%。PET/CT的检测率、灵敏度和阳性预测值均优于专用PET（p<0.01）。
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