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髂腔静脉支架置入术联合手术取栓的远期疗效

Late results of surgical venous thrombectomy with iliocaval stenting.

作者信息

Hartung Olivier, Benmiloud Fares, Barthelemy Pierre, Dubuc Myriam, Boufi Mourad, Alimi Yves S

机构信息

Service de Chirurgie Vasculaire, Centre Hospitalier Universitaire Nord, Marseille, France.

出版信息

J Vasc Surg. 2008 Feb;47(2):381-7. doi: 10.1016/j.jvs.2007.10.007.

Abstract

PURPOSE

Iliac vein occlusive disease leads to 73% of rethrombosis that occurs after venous thrombectomy when left untreated. The goal of this study is to present our long-term results of stenting of iliocaval occlusive lesions persisting after surgical venous thrombectomy.

METHODS

From November 1995 to April 2007, 29 patients (19 women), with a median age of 38 years, had surgical venous thrombectomy with creation of an arteriovenous fistula and angioplasty and stenting. All were admitted for acute (<10 days) deep venous thrombosis (DVT) involving the iliocaval segment, of which eight had concomitant acute pulmonary embolism. Six patients had a history of DVT (2 with previous venous thrombectomy), two were pregnant, and three had postpartum DVT. No patients had short- or mid-term life-threatening factors. The underlying lesion was left iliocaval compression (May-Thurner syndrome) in 22 patients, chronic left common iliac vein occlusion in 3, residual clot in 3, and compression of the left external iliac vein by the left internal iliac artery in 1.

RESULTS

Neither perioperative death nor pulmonary embolism occurred. Four early complications occurred after stenting (13.8%). Median hospital length of stay was 8 days (range, 5-22 days). Median follow-up was 63 months (range, 2-137 months). Three late complications occurred (10.3 %): one rethrombosis due to stent crushing during pregnancy and two restenosis, which were treated by iterative stenting. At the end of the follow-up, the median venous clinical severity score was 3 (range 1-12) and the venous disability score was 1 (range 0-2). Primary, assisted primary and secondary patency rates were, respectively, 79%, 86%, and 86% at 12, 60, and 120 months. Patients with patent iliocaval segments had significantly fewer infrainguinal obstructive lesions (4% vs 50%) and a higher rate of valvular competence (76% vs 0%) than those who experienced rethrombosis. Venous scores were also worse in patients with rethrombosis.

CONCLUSION

Stenting is a safe, efficient, and durable technique to treat occlusive iliocaval disease after venous thrombectomy. Its use can prevent most of the rethrombosis that occurs after venous thrombectomy without major adverse effects.

摘要

目的

髂静脉闭塞性疾病若不治疗,会导致静脉血栓切除术后73%的患者再次发生血栓形成。本研究的目的是展示我们对手术静脉血栓切除术后持续存在的髂腔静脉闭塞性病变进行支架置入的长期结果。

方法

1995年11月至2007年4月,29例患者(19例女性),中位年龄38岁,接受了手术静脉血栓切除术,并建立动静脉瘘、血管成形术和支架置入术。所有患者均因累及髂腔静脉段的急性(<10天)深静脉血栓形成(DVT)入院,其中8例伴有急性肺栓塞。6例患者有DVT病史(2例曾接受静脉血栓切除术),2例为孕妇,3例为产后DVT。无患者有短期或中期危及生命的因素。22例患者的潜在病变为左髂腔静脉受压(May-Thurner综合征),3例为慢性左髂总静脉闭塞,3例为残留血栓,1例为左髂内动脉压迫左髂外静脉。

结果

围手术期无死亡病例,也未发生肺栓塞。支架置入后发生4例早期并发症(13.8%)。中位住院时间为8天(范围5 - 22天)。中位随访时间为63个月(范围2 - 137个月)。发生3例晚期并发症(10.3%):1例因孕期支架受压导致再次血栓形成,2例为再狭窄,均通过反复支架置入治疗。随访结束时,中位静脉临床严重程度评分为3分(范围1 - 12分),静脉残疾评分为1分(范围0 - 2分)。12个月、60个月和120个月时的原发性、辅助原发性和继发性通畅率分别为79%、86%和86%。髂腔静脉段通畅的患者与再次发生血栓形成的患者相比,其腹股沟下阻塞性病变明显较少(4%对50%),瓣膜功能正常率较高(76%对0%)。再次发生血栓形成的患者静脉评分也更差。

结论

支架置入术是治疗静脉血栓切除术后闭塞性髂腔静脉疾病的一种安全、有效且持久的技术。其应用可预防静脉血栓切除术后发生的大多数再次血栓形成,且无重大不良反应。

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