胆汁淤积的机制。
Mechanisms of cholestasis.
作者信息
Zollner Gernot, Trauner Michael
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Laboratory of Experimental and Molecular Hepatology, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria.
出版信息
Clin Liver Dis. 2008 Feb;12(1):1-26, vii. doi: 10.1016/j.cld.2007.11.010.
This article gives an overview of the molecular and cellular mechanisms of cholestasis. Topics reviewed include the pathomechanisms of hereditary cholestasis syndromes, such as progressive familial intrahepatic cholestasis, and hepatocellular transporter defects encountered in various acquired cholestatic disorders, such as intrahepatic cholestasis of pregnancy, drug-induced cholestasis, inflammatory cholestasis, primary sclerosing cholangitis, and primary biliary cirrhosis. In addition, current concepts regarding adaptive hepatocellular mechanisms counteracting cholestatic liver damage are discussed.
本文概述了胆汁淤积的分子和细胞机制。所综述的主题包括遗传性胆汁淤积综合征的发病机制，如进行性家族性肝内胆汁淤积，以及在各种获得性胆汁淤积性疾病中遇到的肝细胞转运体缺陷，如妊娠期肝内胆汁淤积、药物性胆汁淤积、炎症性胆汁淤积、原发性硬化性胆管炎和原发性胆汁性肝硬化。此外，还讨论了关于对抗胆汁淤积性肝损伤的适应性肝细胞机制的当前概念。
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