利什曼病的化疗 第八部分：新型查耳酮的合成与生物评价
Chemotherapy of leishmaniasis part-VIII: synthesis and bioevaluation of novel chalcones.
作者信息
Suryawanshi S N, Chandra Naveen, Kumar Pawan, Porwal Jyoti, Gupta Suman
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, India.
出版信息
Eur J Med Chem. 2008 Nov;43(11):2473-8. doi: 10.1016/j.ejmech.2007.12.014. Epub 2007 Dec 27.
PMID:18243420
Abstract
Some novel dihydro-alpha-ionone based chalcones have been synthesized and evaluated for their in vitro antileishmanial activity in promastigote and amastigote model. Some of the compounds showed 100% inhibition at 5 and 2 microm/ml concentration.
摘要
一些新型的基于二氢-α-紫罗兰酮的查耳酮已被合成，并在前鞭毛体和无鞭毛体模型中对其体外抗利什曼原虫活性进行了评估。一些化合物在5和2微克/毫升的浓度下显示出100%的抑制率。
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