Romanowicz Michael, Stephenson Judith J, Del Rosso James Q, Lenhart Greg
Managed Care & Professional Affairs, CollaGenex Pharmaceuticals, Inc, Newtown, PA 18940, USA.
J Drugs Dermatol. 2008 Jan;7(1):41-9.
Rosacea is a chronic, relapsing dermatologic condition that affects an estimated 14 million people in the U.S. However, there is little data in the literature on the healthcare utilization and costs of patients with rosacea in insured populations.
This retrospective, observational, cohort study used the MarketScan databases to identify a rosacea cohort of patients with medical and prescription drug claims between 2002 and 2005. Inclusion criteria were (1) age 30 years and older, (2) at least one medical claim with a primary or secondary diagnosis of rosacea (ICD-9-CM 695.3), (3) at least one pharmacy claim for a rosacea topical or systemic prescription drug, (4) a 6-month clean period prior to index drug and 12 months continuous enrollment after the index drug. Propensity score matching was used to match the rosacea cohort to a control group of patients without rosacea. Disease severity during the 6-month preperiod was assessed by the Charlson Comorbidity Index (CCI), the Chronic Disease Score (CDS), and the Elixhauser Index (EI). Healthcare utilization rates and costs were determined by the type of care for the 12-month postperiod. Costs were calculated for the 12-month post-period and adjusted to reflect 2005 costs. Healthcare utilization rates and costs were reported for inpatient hospital admissions, physician office visits, emergency room visits, other outpatient services, and outpatient pharmacy prescriptions. Both total healthcare and rosacea-related rates and costs were reported.
There were no rosacea-related inpatient admissions and very few emergency department visits. More rosacea patients had a specialist visit than a primary care physician visit. The average number of rosacea-related prescriptions, for all patients, was 3.4 (SD 2.7) per year. Total annual healthcare expenditures for the rosacea patient cohort were $735 more than for the matched controls ($6,458 vs. $5,723). Of the total healthcare costs, annual rosacea-related expenditures were $276; approximately 70% of rosacea-related expenditures were due to prescription drugs. Topical drugs were the index drugs for 77% of rosacea patients with branded metronidazole, which is the most common topical drug. Of the 23% of rosacea patients with an oral index drug, generic antibiotic dosage forms of tetracyclines were the most common oral index drug therapy.
This is the first extensive study of rosacea and its impact on healthcare utilization and costs in an insured population. Although rosacea is a common illness that does not have much financial impact on its sufferers, rosacea patients incurred slightly higher direct total healthcare costs than matched controls.
酒渣鼻是一种慢性复发性皮肤病,据估计美国有1400万人受其影响。然而,关于参保人群中酒渣鼻患者的医疗服务利用情况和费用,文献中的数据很少。
这项回顾性观察队列研究使用MarketScan数据库,确定了2002年至2005年间有医疗和处方药索赔的酒渣鼻患者队列。纳入标准为:(1)年龄30岁及以上;(2)至少有一项主要或次要诊断为酒渣鼻(国际疾病分类第九版临床修订本695.3)的医疗索赔;(3)至少有一项酒渣鼻局部或全身处方药的药房索赔;(4)在索引药物之前有6个月的清洁期,在索引药物之后连续注册12个月。倾向评分匹配用于将酒渣鼻队列与无酒渣鼻的对照组患者进行匹配。通过查尔森合并症指数(CCI)、慢性病评分(CDS)和埃利克斯豪泽指数(EI)评估6个月前期的疾病严重程度。医疗服务利用率和费用由12个月后期的护理类型确定。计算12个月后期的费用并进行调整以反映2005年的费用。报告了住院入院、医生门诊、急诊就诊、其他门诊服务和门诊药房处方的医疗服务利用率和费用。报告了总医疗费用以及与酒渣鼻相关的费用和利用率。
没有与酒渣鼻相关的住院治疗,急诊就诊也很少。酒渣鼻患者看专科医生的次数多于看初级保健医生的次数。所有患者每年与酒渣鼻相关的处方平均数量为3.4(标准差2.7)。酒渣鼻患者队列的年度总医疗支出比匹配的对照组多735美元(6458美元对5723美元)。在总医疗费用中,年度与酒渣鼻相关的支出为276美元;与酒渣鼻相关的支出中约70%是由于处方药。局部用药是77%酒渣鼻患者的索引药物,品牌甲硝唑是最常见的局部用药。在23%有口服索引药物的酒渣鼻患者中,四环素类通用抗生素剂型是最常见的口服索引药物治疗。
这是第一项关于酒渣鼻及其对参保人群医疗服务利用和费用影响的广泛研究。虽然酒渣鼻是一种常见疾病,对患者没有太大的经济影响,但酒渣鼻患者的直接总医疗费用略高于匹配的对照组。