内源性大麻素系统：癌症潜在的治疗靶点？

The endocannabinoid system in cancer-potential therapeutic target?

作者信息

Flygare Jenny, Sander Birgitta

机构信息

Department of Laboratory Medicine, Divison of Pathology, F46, Karolinska Institutet and Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden.

出版信息

Semin Cancer Biol. 2008 Jun;18(3):176-89. doi: 10.1016/j.semcancer.2007.12.008. Epub 2007 Dec 14.

DOI:10.1016/j.semcancer.2007.12.008

PMID:18249558

Abstract

Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy. In this review we discuss various means by which the endocannabinoid system may be targeted in cancer and the current knowledge considering the regulation of the endocannabinoid system in malignancy.

摘要

具有与大麻（Cannabis sativa Linnaeus）化合物相似特性的内源性花生四烯酸代谢产物，即所谓的内源性大麻素，对多种类型的癌症都有影响。尽管内源性大麻素和合成大麻素可能具有促增殖作用，但主要还是描述了它们对肿瘤生长、血管生成、迁移和转移的抑制作用。值得注意的是，这些作用可能对癌细胞具有选择性，而正常细胞和组织则不受影响。这种明显的肿瘤细胞选择性使得内源性大麻素系统成为癌症治疗中一个有吸引力的潜在靶点。在这篇综述中，我们讨论了在内源性大麻素系统在癌症中可能成为靶点的各种方式，以及目前关于恶性肿瘤中内源性大麻素系统调节的知识。