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对于卵巢低反应的卵胞浆内单精子注射患者，口服避孕药预处理并不能改善微剂量促性腺激素释放激素激动剂方案的结局。

Oral contraceptive pretreatment does not improve outcome in microdose gonadotrophin-releasing hormone agonist protocol among poor responder intracytoplasmic sperm injection patients.

作者信息

Duvan Candan Iltemir, Berker Bulent, Turhan Nilgun Ozturk, Satiroglu Hakan

机构信息

IVF Unit, Fatih University Medical School, Ankara, Turkey.

出版信息

J Assist Reprod Genet. 2008 Feb-Mar;25(2-3):89-93. doi: 10.1007/s10815-008-9203-8. Epub 2008 Feb 6.

DOI:10.1007/s10815-008-9203-8
PMID:18253823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2582111/
Abstract

PURPOSE

To compare oral contraceptive (OC) pretreatment plus microdose GnRH-a in flare-up protocol and non-OC microdose GnRH-a in flare-up protocol among poor responder ICSI patients.

METHODS

A retrospective analysis of poor responder ICSI patients. Patients were divided into two groups according to used microdose protocol. Precycle treatment with OC followed by follicular phase administration of 40 microg s.c. leuprolide acetate (LA) every 12 h beginning on after 2 day pill-free period and rFSH administration was begun on the third day of LA administration (OC-Group, n=26). Alternatively on day 2 after menses, patients were administered similar stimulation regime (non-OC Group, n=27).

RESULTS

There were no significant differences between groups in the number of oocytes, peak estradiol levels, endometrial thickness, fertilization rates and embryo quality. Implantations and pregnancy rates per embryo transfer were similar.

CONCLUSION

OC pretreatment plus microdose GnRHa in flare-up protocol does not offer advantages over non-OC microdose GnRHa in flare-up protocol among poor responder ICSI patients.

摘要

目的

比较在卵巢低反应性的卵胞浆内单精子注射（ICSI）患者中，口服避孕药（OC）预处理联合小剂量促性腺激素释放激素激动剂（GnRH-a）的激发方案与非OC小剂量GnRH-a激发方案的效果。

方法

对卵巢低反应性的ICSI患者进行回顾性分析。根据所采用的小剂量方案将患者分为两组。在月经周期前用OC进行预处理，随后在停药2天后开始卵泡期皮下注射40μg醋酸亮丙瑞林（LA），每12小时1次，并在LA注射第3天开始给予重组促卵泡素（rFSH）（OC组，n = 26）。或者在月经来潮后第2天，给予患者类似的刺激方案（非OC组，n = 27）。

结果

两组在获卵数、雌二醇峰值水平、子宫内膜厚度、受精率和胚胎质量方面无显著差异。每次胚胎移植的着床率和妊娠率相似。

结论

在卵巢低反应性的ICSI患者中，OC预处理联合小剂量GnRHa激发方案并不比非OC小剂量GnRHa激发方案更具优势。

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本文引用的文献

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Hypothalamic-pituitary suppression with oral contraceptive pills does not improve outcome in poor responder patients undergoing in vitro fertilization-embryo transfer cycles.
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