款冬花蕾化学成分的研究

[Studies on chemical constituents in the buds of Tussilago farfara].

作者信息

Liu Yu-feng, Yang Xiu-wei, Wu Bin

机构信息

Department of Natural Medicines, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(22):2378-81.

PMID:18257263

Abstract

OBJECTIVE

To study the chemical constituents in the buds of Tussilago farfara.

METHOD

The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by NMR and MS evidences.

RESULT

Eleven compounds were obtained and identified as methyl 3, 4-O-dicaffeoylquinate (1), methyl 3, 5-O-dicaffeoylquinate (2), methyl 4, 5-O-dicaffeoylquinate (3), 3, 5-O-dicaffeoylquinic acid (4), methyl 3-O-caffeoylquinate (5), 3-O-caffeoylquinic acid (6), hyperoside (7), rutin (8), kaempferol 3-O-beta-D-glucopyranoside (9), quercetin (10), and kaempferol (11).

CONCLUSION

Compounds 2-5 were isolated from the genus for the first time.

摘要

目的

研究款冬花蕾中的化学成分。

方法

采用多种柱色谱方法分离化学成分，并通过核磁共振（NMR）和质谱（MS）证据对其结构进行鉴定。

结果

得到11个化合物，分别鉴定为3,4-O-二咖啡酰奎宁酸甲酯（1）、3,5-O-二咖啡酰奎宁酸甲酯（2）、4,5-O-二咖啡酰奎宁酸甲酯（3）、3,5-O-二咖啡酰奎宁酸（4）、3-O-咖啡酰奎宁酸甲酯（5）、3-O-咖啡酰奎宁酸（6）、金丝桃苷（7）、芦丁（8）、山柰酚3-O-β-D-葡萄糖苷（9）、槲皮素（10）和山柰酚（11）。