血管紧张素II和III通过血管紧张素AT(2)受体和前列腺素EP(4)受体抑制小鼠的食物摄入量。
Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice.
作者信息
Ohinata Kousaku, Fujiwara Yoko, Fukumoto Shingo, Iwai Masaru, Horiuchi Masatsugu, Yoshikawa Masaaki
机构信息
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan.
出版信息
FEBS Lett. 2008 Mar 5;582(5):773-7. doi: 10.1016/j.febslet.2008.01.054. Epub 2008 Feb 5.
Intracerebroventricularly administered angiotensin (Ang) II and III dose-dependently suppressed food intake in mice and their anorexigenic activities were inhibited by AT(2) receptor-selective antagonist. Ang II did not suppress food intake in AT(2) receptor-knockout mice, while it did significantly in wild-type and AT(1) receptor-knockout mice. The suppression of food intake in AT(1) receptor-knockout mice was smaller than that in wild-type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP(4) receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT(2) receptor with partial involvement of AT(1) receptor, followed by EP(4) receptor activation, which is a novel pathway regulating food intake.
脑室内注射血管紧张素（Ang）II和III可剂量依赖性地抑制小鼠的食物摄入，其厌食活性可被AT(2)受体选择性拮抗剂抑制。Ang II对AT(2)受体基因敲除小鼠的食物摄入无抑制作用，而对野生型和AT(1)受体基因敲除小鼠有显著抑制作用。AT(1)受体基因敲除小鼠的食物摄入抑制作用小于野生型小鼠。Ang II和III的厌食活性也被前列腺素EP(4)受体选择性拮抗剂阻断。综上所述，中枢给予Ang II和III可能通过AT(2)受体降低食物摄入，部分涉及AT(1)受体，随后激活EP(4)受体，这是一种调节食物摄入的新途径。
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