Jazet I M, Meinders A E
Leids Universitair Medisch Centrum, afd. Algemene Interne Geneeskunde, Leiden.
Ned Tijdschr Geneeskd. 2008 Jan 19;152(3):132-8.
--The incidence of type 2 diabetes mellitus is increasing, as is the rate of related long-term complications. --Increased body weight and lack of exercise are the major non-genetic factors that are responsible for the increased incidence of type 2 diabetes mellitus. --People predisposed to developing type 2 diabetes mellitus can be identified easily by taking a patient history (e.g. genetic predisposition, gestational diabetes, medication), performing a physical examination (e.g. body-mass index, fat distribution) and laboratory tests (e.g. impaired fasting and post-load blood glucose levels). --Intensive lifestyle modifications reduce the risk of type 2 diabetes mellitus by 42-58%. --Drug therapy is less effective than lifestyle modifications in the prevention of type 2 diabetes mellitus. Moreover, the disease course after treatment is discontinued is unknown. --Successful intervention resulting in a sustained effect is expected to have a preventive effect on the long-term complications of type 2 diabetes mellitus.
——2型糖尿病的发病率在上升,相关长期并发症的发生率也在上升。
——体重增加和缺乏运动是导致2型糖尿病发病率上升的主要非遗传因素。
——通过询问患者病史(如遗传易感性、妊娠期糖尿病、用药情况)、进行体格检查(如体重指数、脂肪分布)和实验室检查(如空腹及负荷后血糖水平受损),可以轻松识别易患2型糖尿病的人群。
——强化生活方式改变可将2型糖尿病风险降低42%至58%。
——在预防2型糖尿病方面,药物治疗不如生活方式改变有效。此外,停药后的疾病进程尚不清楚。
——成功的干预并产生持续效果有望对2型糖尿病的长期并发症起到预防作用。