N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
作者信息
Liang Gui-Bai, Qian Xiaoxia, Feng Dennis, Fisher Michael, Crumley Tami, Darkin-Rattray Sandra J, Dulski Paula M, Gurnett Anne, Leavitt Penny Sue, Liberator Paul A, Misura Andrew S, Samaras Samantha, Tamas Tamas, Schmatz Dennis M, Wyvratt Matthew, Biftu Tesfaye
机构信息
Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2008 Mar 15;18(6):2019-22. doi: 10.1016/j.bmcl.2008.01.104. Epub 2008 Feb 2.
Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.
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