Mostachio Giuliano Q, de-Oliveira Luciana D, Carciofi Aulus C, Vicente Wilter R R
Department of Clinical and Surgery, Faculty of Veterinary and Agriculture Sciences, São Paulo State University, Jaboticabal, Brazil.
Vet Anaesth Analg. 2008 May;35(3):232-6. doi: 10.1111/j.1467-2995.2007.00381.x. Epub 2008 Feb 18.
To examine the anesthetic effects of a xylazine-diazepam-ketamine (XDK) combination in roosters.
Prospective experimental trial.
Six healthy white Leghorn roosters weighing 2.03 +/- 0.08 kg.
Each rooster was pre-medicated with xylazine (3 mg kg(-1), IM) and after 15 minutes anesthesia was induced with a diazepam (4 mg kg(-1)) and ketamine (25 mg kg(-1)) combination injected into the pectoral muscles. Heart and respiratory rates were recorded before anesthesia and every 15 minutes after induction for 165 minutes. Cloacal temperature was measured before and 15 minutes after pre-medication and every 75 minutes thereafter during anesthesia. Quality of induction and recovery were scored subjectively; duration of loss of righting reflex, abolition of response to a painful stimulus and palpebral reflex were also recorded.
Intramuscular injection of xylazine smoothly induced loss of the righting reflex within 3-4 minutes. Loss of response to a painful stimulus occurred at 13.1 +/- 2.9 minutes (mean +/- SD) after the administration of the D-K combination, and lasted for 63.0 +/- 5.3 minutes. Roosters anesthetized with this combination had a significant decrease in heart and respiratory rates and cloacal temperature. The recovery period lasted for up to 4 hours (227.5 +/- 15.4 minutes). Quality of recovery was satisfactory for four roosters but excitation was noted in two birds.
The XDK combination was a useful anesthetic technique for typhlectomy in roosters. Nevertheless this drug combination should be used with caution and cardiopulmonary parameters monitored carefully. Under the conditions of this experiment it was associated with a decreased cloacal temperature and prolonged recoveries.
研究赛拉嗪 - 地西泮 - 氯胺酮(XDK)合剂对公鸡的麻醉效果。
前瞻性实验性试验。
6只健康白色来航公鸡,体重2.03±0.08千克。
每只公鸡预先肌注赛拉嗪(3毫克/千克),15分钟后通过胸肌注射地西泮(4毫克/千克)和氯胺酮(25毫克/千克)合剂诱导麻醉。在麻醉前以及诱导后每15分钟记录一次心率和呼吸频率,持续165分钟。在术前用药前及用药后15分钟测量泄殖腔温度,麻醉期间此后每75分钟测量一次。主观评定诱导和苏醒质量;记录翻正反射消失、对疼痛刺激反应消失及眼睑反射消失的持续时间。
肌注赛拉嗪后3 - 4分钟内可平稳诱导翻正反射消失。给予D - K合剂后13.1±2.9分钟(均值±标准差)出现对疼痛刺激反应消失,持续63.0±5.3分钟。用此合剂麻醉的公鸡心率、呼吸频率和泄殖腔温度显著降低。苏醒期长达4小时(227.5±15.4分钟)。4只公鸡苏醒质量满意,但有2只出现兴奋现象。
XDK合剂是用于公鸡盲肠切除术的一种有效的麻醉技术。然而,使用此药物合剂时应谨慎,并仔细监测心肺参数。在本实验条件下它与泄殖腔温度降低及苏醒时间延长有关。