特殊细胞，特殊考量：将胚胎干细胞从实验室应用于临床所面临的挑战。
Special cells, special considerations: the challenges of bringing embryonic stem cells from the laboratory to the clinic.
作者信息
Addis R C, Bulte J W M, Gearhart J D
出版信息
Clin Pharmacol Ther. 2008 Mar;83(3):386-9. doi: 10.1038/sj.clpt.6100384.
Abstract
Human embryonic stem (ES) cells are an attractive tool for cell-based therapies because of their limitless capacity for proliferation and their ability to differentiate into all cell types of the body. However, these features introduce certain unique risks that must be considered in developing transplantation strategies for clinical use. We outline these risks and examine current approaches to address them, both before and after transplantation.
摘要
人类胚胎干细胞（ES细胞）因其无限的增殖能力以及分化为机体所有细胞类型的能力，成为基于细胞治疗的一种有吸引力的工具。然而，这些特性带来了某些独特风险，在开发临床应用的移植策略时必须加以考虑。我们概述这些风险，并研究在移植前后应对这些风险的当前方法。
相似文献
1
Special cells, special considerations: the challenges of bringing embryonic stem cells from the laboratory to the clinic.
Clin Pharmacol Ther. 2008 Mar;83(3):386-9. doi: 10.1038/sj.clpt.6100384.
2
Human embryonic stem cell research: an Australian perspective.
Cell. 2007 Jan 26;128(2):221-3. doi: 10.1016/j.cell.2007.01.008.
3
Translating stem cells to the clinic: the good, the bad, and the ugly.
Ann Neurol. 2008 Mar;63(3):A17-21. doi: 10.1002/ana.21253.
4
[New progress in cytological treatment of the heart: cardiac stem cells].
Zhonghua Yi Xue Za Zhi. 2007 Nov 27;87(44):3097-9.
5
Stem cell therapy: the expectations, considerations, and clinical research issues.
Adv Skin Wound Care. 2011 Nov;24(11):496. doi: 10.1097/01.ASW.0000407651.35703.1b.
6
Human embryonic stem cells: preclinical perspectives.
J Transl Med. 2008 Jan 29;6:7. doi: 10.1186/1479-5876-6-7.
7
Stem cells and development in Latin America.
Stem Cells Dev. 2010 Mar;19(3):283-4. doi: 10.1089/scd.2010.1903.edi.
8
Induced pluripotent stem cells: it's like déjà vu all over again.
Circulation. 2009 Oct 13;120(15):1462-4. doi: 10.1161/CIRCULATIONAHA.109.898544. Epub 2009 Sep 28.
9
Cell transplantation: toward cell therapy.
Cell Transplant. 2006;15(7):665-73. doi: 10.3727/000000006783981666.
10
Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease.
Neuron. 2009 Feb 12;61(3):337-9. doi: 10.1016/j.neuron.2009.01.024.
引用本文的文献
1
Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features.
Sci Rep. 2016 Mar 31;6:23453. doi: 10.1038/srep23453.
2
Personalized nanomedicine advancements for stem cell tracking.
Adv Drug Deliv Rev. 2012 Oct;64(13):1488-507. doi: 10.1016/j.addr.2012.07.008. Epub 2012 Jul 20.
3
Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle.
PLoS One. 2011 Feb 3;6(2):e16816. doi: 10.1371/journal.pone.0016816.
4
From structure to cellular mechanism with infrared microspectroscopy.
Curr Opin Struct Biol. 2010 Oct;20(5):649-56. doi: 10.1016/j.sbi.2010.07.007. Epub 2010 Aug 24.
5
Human ESC vs. iPSC-pros and cons.
J Cardiovasc Transl Res. 2008 Jun;1(2):96-9. doi: 10.1007/s12265-008-9032-2. Epub 2008 May 30.
6
Optical spectroscopy for noninvasive monitoring of stem cell differentiation.
J Biomed Biotechnol. 2010;2010:101864. doi: 10.1155/2010/101864. Epub 2010 Feb 16.
7
Genetic control of wayward pluripotent stem cells and their progeny after transplantation.
Cell Stem Cell. 2009 Apr 3;4(4):289-300. doi: 10.1016/j.stem.2009.03.010.
本文引用的文献
1
Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells seeded on collagen scaffolds-relevance to tissue engineering.
Tissue Eng. 2006 Oct;12(10):2765-75. doi: 10.1089/ten.2006.12.2765.
2
Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene.
Mol Ther. 2007 Jul;15(7):1373-81. doi: 10.1038/sj.mt.6300155. Epub 2007 Apr 24.
3
Identification and selection of cardiomyocytes during human embryonic stem cell differentiation.
FASEB J. 2007 Aug;21(10):2551-63. doi: 10.1096/fj.05-5711com. Epub 2007 Apr 13.
4
Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Cloning Stem Cells. 2007 Spring;9(1):107-17. doi: 10.1089/clo.2006.0E16.
5
A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells.
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4449-54. doi: 10.1073/pnas.0700052104. Epub 2007 Mar 2.
6
Magnetoelectroporation: improved labeling of neural stem cells and leukocytes for cellular magnetic resonance imaging using a single FDA-approved agent.
Nanomedicine. 2006 Jun;2(2):89-94. doi: 10.1016/j.nano.2006.01.003.
7
MRI of intravenously injected bone marrow cells homing to the site of injured arteries.
NMR Biomed. 2007 Nov;20(7):673-81. doi: 10.1002/nbm.1128.
8
Artificial reporter gene providing MRI contrast based on proton exchange.
Nat Biotechnol. 2007 Feb;25(2):217-9. doi: 10.1038/nbt1277. Epub 2007 Jan 28.
9
Transplanted human neural precursor cells migrate widely but show no lesion-specific tropism in the 6-hydroxydopamine rat model of Parkinson's disease.
Cell Transplant. 2006;15(7):579-93. doi: 10.3727/000000006783981684.
10
Tracking neural stem cells in patients with brain trauma.
N Engl J Med. 2006 Nov 30;355(22):2376-8. doi: 10.1056/NEJMc055304.
Zotero 插件