Pandey Preetanshu, Ewing Gary D
Oral and Respiratory Product Development,, Schering-Plough Research Institute, Summit, New Jersey 07901, USA.
Drug Dev Ind Pharm. 2008 Feb;34(2):157-63. doi: 10.1080/03639040701484569.
The current study focuses on characterizing the rheological characteristics of different petrolatum grades using a controlled stress rheometer. Both steady-state flow and dynamic oscillatory tests were conducted on the petrolatums. The thermorheological scans were found to be the most informative and reproducible for this study. Significant differences in the structure were observed between the petrolatum grades. The structural differences were found to be most significant in the temperature range 25-35 degrees C. The findings from this study will help in identifying the critical parameters (for e.g., temperature, mixing) during the processing and handling of such materials, which can have a direct impact on the product rheology and performance.
当前的研究聚焦于使用控制应力流变仪来表征不同等级凡士林的流变特性。对凡士林进行了稳态流动和动态振荡测试。结果发现,热流变扫描对于本研究而言信息最为丰富且具有可重复性。在不同等级的凡士林之间观察到了显著的结构差异。这些结构差异在25至35摄氏度的温度范围内最为显著。本研究的结果将有助于确定在此类材料的加工和处理过程中的关键参数(例如温度、混合),这些参数会对产品的流变学和性能产生直接影响。