循环基质细胞衍生因子-1α（SDF-1α）可预测胃癌的远处转移。

Circulating stromal cell derived factor-1alpha (SDF-1alpha) is predictive of distant metastasis in gastric carcinoma.

作者信息

Woo In Sook, Hong Sook Hee, Byun Jae Ho, Kang Jin-Hyung, Jeon Hae-Myung, Choi Myung Gyu

机构信息

Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea.

出版信息

Cancer Invest. 2008 Apr-May;26(3):256-61. doi: 10.1080/07357900701684057.

DOI:10.1080/07357900701684057

PMID:18317966

Abstract

This study was conducted to investigate the value of the pretreatment circulating stromal cell derived factor-1alpha(SDF-1alpha) in patients with gastric carcinoma. We measured SDF-1alpha serum concentrations and evaluated the relationship between serum SDF-1alpha and serum vascular endothelial growth factor (VEGF) levels and clinical factors in 107 gastric cancer patients. Serum levels of SDF-1alpha and VEGF levels were higher in gastric cancer patients than in controls (p < 0.001). Serum SDF-1alpha levels were higher in metastatic patients than non-metastatic patients (p < 0.001). SDF-1alpha levels were correlated with the presence of distant metastases (r = 0.528; p < 0.001) and correlated with VEGF levels (r = 0.789; p < 0.001). SDF-1alpha might serve as a possible marker for predicting or monitoring distant metastasis in gastric carcinoma.

摘要

本研究旨在探讨胃癌患者治疗前循环基质细胞衍生因子-1α（SDF-1α）的价值。我们检测了107例胃癌患者的SDF-1α血清浓度，并评估血清SDF-1α与血清血管内皮生长因子（VEGF）水平及临床因素之间的关系。胃癌患者的血清SDF-1α和VEGF水平高于对照组（p<0.001）。转移患者的血清SDF-1α水平高于非转移患者（p<0.001）。SDF-1α水平与远处转移的存在相关（r=0.528；p<0.001），并与VEGF水平相关（r=0.789；p<0.001）。SDF-1α可能作为预测或监测胃癌远处转移的一个潜在标志物。