颞下颌关节紊乱病的药物治疗

Pharmacologic management of temporomandibular disorders.

作者信息

Hersh Elliot V, Balasubramaniam Ramesh, Pinto Andres

机构信息

Department of Oral Surgery and Pharmacology, University of Pennsylvania, School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104-6030, USA.

出版信息

Oral Maxillofac Surg Clin North Am. 2008 May;20(2):197-210, vi. doi: 10.1016/j.coms.2007.12.005.

DOI:10.1016/j.coms.2007.12.005

PMID:18343325

Abstract

Although there are theoretically numerous pharmacologic targets for relieving temporomandibular disorder (TMD)-associated pains, evidence-based literature clearly establishing the efficacy and safety of drugs in the TMD population is limited at best. This article reviews the pharmacology, toxicology, and research supporting the use of a host of pharmacologic agents that have been used in patients who have TMD, including nonsteroidal anti-inflammatory drugs, corticosteroids, benzodiazepines, nonbenzodiazepine sedative hypnotics, opioids, skeletal muscle relaxants, capsaicin, transdermal lidocaine, antidepressants, and anticonvulsants. Recommendations regarding the proper use of each drug class are also made.

摘要

尽管理论上有众多缓解颞下颌关节紊乱症（TMD）相关疼痛的药理学靶点，但能明确证实药物在TMD患者群体中有效性和安全性的循证文献充其量也很有限。本文回顾了一系列曾用于TMD患者的药物的药理学、毒理学及相关研究，这些药物包括非甾体抗炎药、皮质类固醇、苯二氮䓬类药物、非苯二氮䓬类镇静催眠药、阿片类药物、骨骼肌松弛剂、辣椒素、透皮利多卡因、抗抑郁药和抗惊厥药。文中还针对各类药物的合理使用给出了建议。