Bonakis Anastasios, Howard Robin S, Williams Adrian
Sleep Disorder Centre, Guy's and St. Thomas' NHS Foundation Trust, Lambeth Palace Road, London SE17EH, UK.
Clin Neurol Neurosurg. 2008 May;110(5):518-20. doi: 10.1016/j.clineuro.2008.01.015. Epub 2008 Mar 17.
REM sleep behaviour disorder (RBD) is a neurological condition well known to be associated with the synucleinopathies in middle-aged patients. However, there is much less data concerning its development, evolution, and association with other disorders in younger patients. We report two patients aged less than 33 years who presented with clinical and polysomnographical features of RBD, both of whom proved to have previously undiagnosed narcolepsy. Whilst the association of narcolepsy with RBD has been previously recognised, this is the first report of narcoleptic patients presenting with RBD. Narcolepsy should be included in the differential diagnosis of young patients presenting with abnormal behaviour during sleep compatible with RBD.
快速眼动睡眠行为障碍(RBD)是一种神经系统疾病,在中年患者中众所周知与突触核蛋白病相关。然而,关于其在年轻患者中的发展、演变以及与其他疾病的关联的数据要少得多。我们报告了两名年龄小于33岁的患者,他们表现出RBD的临床和多导睡眠图特征,两人均被证明患有先前未诊断出的发作性睡病。虽然发作性睡病与RBD的关联此前已被认识到,但这是首次报告发作性睡病患者出现RBD。对于出现与RBD相符的睡眠期间异常行为的年轻患者,鉴别诊断中应包括发作性睡病。