原发性膝骨关节炎患者滑液中骨保护素（OPG）水平升高以及血清中核因子κB受体活化因子配体（RANKL）与OPG的比值增加与疾病严重程度相关。
High levels of synovial fluid osteoprotegerin (OPG) and increased serum ratio of receptor activator of nuclear factor-kappa B ligand (RANKL) to OPG correlate with disease severity in patients with primary knee osteoarthritis.
作者信息
Pilichou Anastasia, Papassotiriou Ioannis, Michalakakou Kelly, Fessatou Smaragdi, Fandridis Emmanuel, Papachristou George, Terpos Evangelos
机构信息
Second Department of Orthopaedics, University of Athens School of Medicine, Athens, Greece.
出版信息
Clin Biochem. 2008 Jun;41(9):746-9. doi: 10.1016/j.clinbiochem.2008.02.011. Epub 2008 Mar 8.
OBJECTIVE
Evaluation of serum and synovial fluid OPG and sRANKL in 37 patients with primary knee osteoarthritis.
DESIGN AND METHOD
OPG and sRANKL were measured using ELISA.
RESULTS
OPG, sRANKL and sRANKL/OPG were increased in osteoarthritis patients' serum. Synovial OPG was higher than serum OPG, while sRANKL/OPG was higher in the serum; both correlated with disease severity.
DISCUSSION
RANKL/OPG pathway is implicated in the pathogenesis of knee osteoarthritis being a suitable target for therapeutic intervention.
目的
评估37例原发性膝骨关节炎患者血清和滑液中的骨保护素（OPG）和可溶性核因子κB受体活化因子配体（sRANKL）。
设计与方法
采用酶联免疫吸附测定法（ELISA）检测OPG和sRANKL。
结果
骨关节炎患者血清中的OPG、sRANKL及sRANKL/OPG升高。滑液OPG高于血清OPG，而血清中的sRANKL/OPG更高；二者均与疾病严重程度相关。
讨论
RANKL/OPG通路与膝骨关节炎的发病机制有关，是治疗干预的合适靶点。
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