Dubow Jordan S, Panush Stephanie R, Rezak Michael, Leikin Jerrold
Movement Disorders Center, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Am J Ther. 2008 Mar-Apr;15(2):184-6. doi: 10.1097/MJT.0b013e31815afe5b.
Drug-induced movement disorders are commonly seen in the inpatient setting and outpatient movement disorders centers. The most common acute reactions are dystonia, parkinsonism, and akathisia. Drug-induced movement disorders are classically associated with dopamine receptor blocking agents, most notably typical and atypical antipsychotic medications. However, extrapyramidal side effects can also be seen with antiemetics, promotility drugs, serotonergic agents, and opioid agonists. We describe a patient who developed an acute dystonic reaction shortly after the administration of intravenous foscarnet, an antiviral agent. Her work-up for secondary causes of dystonia was otherwise negative, and her symptoms resolved after receiving intravenous anticholinergic treatment.
药物性运动障碍在住院环境和门诊运动障碍中心较为常见。最常见的急性反应是肌张力障碍、帕金森综合征和静坐不能。药物性运动障碍传统上与多巴胺受体阻断剂有关，最显著的是典型和非典型抗精神病药物。然而，止吐药、促动力药、血清素能药物和阿片类激动剂也可出现锥体外系副作用。我们描述了一名患者，在静脉注射抗病毒药物膦甲酸钠后不久出现急性肌张力障碍反应。她对肌张力障碍继发原因的检查结果为阴性，在接受静脉注射抗胆碱能治疗后症状得到缓解。
