在年轻的城市美洲原住民女性中，体重指数、心肺适能、代谢综合征与空腹血糖受损之间的关联。

Associations between body mass index, cardiorespiratory fitness, metabolic syndrome, and impaired fasting glucose in young, urban native american women.

机构信息

Department of Internal Medicine, Office of Native American Diabetes Programs, Department of Family and Community Medicine, The University of New Mexico Health Sciences Center, School of Medicine, Albuquerque, New Mexico.

出版信息

Metab Syndr Relat Disord. 2007 Spring;5(1):45-54. doi: 10.1089/met.2006.0015.

DOI:10.1089/met.2006.0015

PMID:18370813

Abstract

BACKGROUND

To investigate the baseline associations between body composition, cardiorespiratory fitness, physical activity, family history of type 2 diabetes, metabolic syndrome and impaired fasting glucose (IFG) among 200 asymptomatic urban Native American women aged 18-40 years participating in a diabetes prevention intervention.

METHODS

Participants without diabetes who self-identified as Native American were recruited from the general urban community into a randomized controlled trial. Inclusion criteria included not being pregnant and willingness to stay in the urban area for 2 years. From June 2002 to June 2004, baseline measures were taken and included fasting serum glucose, insulin, and lipids, body mass index (BMI), waist circumference, percent body fat, submaximal predicted cardiorespiratory fitness, and self-reported leisure physical activity and family history of type 2 diabetes.

RESULTS

Most participants were overweight or obese (mean BMI = 29.4 +/- 6.3 kg/m(2); mean percent body fat = 41.2% +/- 6.2%). Fifty-five (27.5%) had metabolic syndrome and 42 (21%) had IFG. Stepwise logistic regression indicated that BMI (odd ratio [OR] = 1.24; p < 0.001) and a family history of type 2 diabetes (OR = 4.96; p = 0.008) were significantly associated with metabolic syndrome. BMI (OR = 1.13; p = 0.003) was strongly positively associated with IFG. After adjusting for BMI, age (OR = 1.08; p = 0.021) was positively, and high-density lipoprotein cholesterol (HDL-C; OR = 0.93; p = 0.008) and cardiorespiratory fitness (OR = 0.36; p = 0.046) were inversely significantly associated with IFG.

CONCLUSIONS

BMI, cardiorespiratory fitness, and physical activity levels are important variables to modify when attempting to reduce the prevalence of metabolic syndrome and IFG among young, asymptomatic Native American women. This information can be used to design effective diabetes prevention interventions.

摘要

背景

本研究旨在调查 200 名无症状的城市美洲原住民年轻女性（18-40 岁）的身体成分、心肺功能适应性、体力活动、2 型糖尿病家族史、代谢综合征和空腹血糖受损（IFG）之间的基线关联，这些女性参与了一项糖尿病预防干预试验。

方法

本研究从城市社区招募了自我认同为美洲原住民的、无糖尿病的参与者，他们被随机分配到一项对照试验中。纳入标准包括未怀孕和愿意在城市地区居住 2 年。从 2002 年 6 月至 2004 年 6 月，进行了基线测量，包括空腹血清葡萄糖、胰岛素和血脂、体重指数（BMI）、腰围、体脂百分比、亚最大预测心肺功能适应性以及自我报告的休闲体力活动和 2 型糖尿病家族史。

结果

大多数参与者超重或肥胖（平均 BMI=29.4±6.3kg/m2；平均体脂百分比=41.2%±6.2%）。55 人（27.5%）患有代谢综合征，42 人（21%）患有 IFG。逐步逻辑回归表明，BMI（比值比[OR]=1.24；p<0.001）和 2 型糖尿病家族史（OR=4.96；p=0.008）与代谢综合征显著相关。BMI（OR=1.13；p=0.003）与 IFG 呈强烈正相关。调整 BMI 后，年龄（OR=1.08；p=0.021）呈正相关，高密度脂蛋白胆固醇（OR=0.93；p=0.008）和心肺功能适应性（OR=0.36；p=0.046）呈负相关。