黏膜相关淋巴组织型原发性肝淋巴瘤：一例细胞遗传学研究病例报告
Primary hepatic lymphoma of mucosa-associated lymphoid tissue type: a case report with cytogenetic study.
作者信息
Koubaa Mahjoub Wafa, Chaumette-Planckaert Marie-Therese, Murga Penas Eva Maria, Dierlamm Judith, Leroy Karen, Delfau Marie-Helene, Loriau Jerome, Gaulard Philippe, Delchier Jean-Charles, Zafrani Elie-Serge, Copie-Bergman Christiane
机构信息
Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Groupe Henri Mondor-Albert Chenevier, Créteil, France.
出版信息
Int J Surg Pathol. 2008 Jul;16(3):301-7. doi: 10.1177/1066896907312671. Epub 2008 Apr 2.
Primary hepatic lymphoma of mucosa-associated lymphoid tissue type is extremely rare. Only 38 cases have been reported to date. A case of a 59-year-old man with Helicobacter pylori-resistant gastric ulcers and Buerger disease who was followed up since 1999 is reported. A 2-cm hepatic nodule was incidentally found during partial gastrectomy and corresponded to mucosa-associated lymphoid tissue-type lymphoma without underlying liver disease. Molecular studies showed a clonal immunoglobulin heavy-chain gene rearrangement. Investigations for the mucosa-associated lymphoid tissue lymphoma-associated translocations t(11;18) and t(14;18), as well as the t(3;14)(q27;q32), were negative, whereas trisomy 3 and trisomy 18 were detected.
黏膜相关淋巴组织型原发性肝淋巴瘤极为罕见。迄今为止，仅报道过38例。本文报告了一例自1999年起接受随访的59岁男性，该患者患有幽门螺杆菌耐药性胃溃疡和布加综合征。在部分胃切除术中偶然发现一个2厘米的肝结节，病理结果为黏膜相关淋巴组织型淋巴瘤，未伴有潜在肝脏疾病。分子研究显示存在克隆性免疫球蛋白重链基因重排。对黏膜相关淋巴组织淋巴瘤相关易位t(11;18)、t(14;18)以及t(3;14)(q27;q32)的检测均为阴性，而检测到了三体3和三体18。
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