Toll样受体

Toll-like receptors.

作者信息

Dasari P, Nicholson I C, Zola H

机构信息

Child Health Research Institute, Women?s and Children?s Hospital, Adelaide, Australia.

出版信息

J Biol Regul Homeost Agents. 2008 Jan-Mar;22(1):17-26.

PMID:18394314

Abstract

Toll-like receptors are a family of transmembrane receptors responsible for recognition and initiation of a response to invading microbes by the immune system. As part of the innate immune system, Toll-like receptors recognise pathogen-associated molecular patterns, highly conserved components that are essential to microbial function. Some of ten toll-like receptors identified in humans are able to recognise several pathogen-associated molecular patterns.

摘要

Toll样受体是一类跨膜受体，负责识别入侵微生物并启动免疫系统的反应。作为先天免疫系统的一部分，Toll样受体识别病原体相关分子模式，即对微生物功能至关重要的高度保守成分。在人类中鉴定出的10种Toll样受体中的一些能够识别几种病原体相关分子模式。