Han Yanfu, Liu Jun
Department of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Mar;22(3):339-42.
To evaluate the effect of autologous free fat particle grafting combined with-bFGF to repair facial depression.
From April 2004 to May 2006, 41 patients with facial depression were randomized into two groups (groups A and B). In group A, 12 cases were admitted from April 2004 to December 2004. There were 5 males and 7 females, aging 16-49 years (mean, 31 years). The pathological causes were congenital facial depression in 2 patients, hemifacial atrophy in 2, traumatic cicatrix in 5 and benign tumor removal in 3. The course of disease was 2-19 years. The concave regions were low (0.52 +/- 0.13) cm compared to surrounding normal skin, concave area (16.0 +/- 5.3) cm2. In group B, 29 cases were admitted from January 2005 to May 2006. There were 14 males and 15 females, aging 18-52 years (mean, 37 years). The pathological causes were: congenital facial depression in 3 patients, hemifacial atrophy in 4, traumatic cicatrix in 15 and benign tumor removal in 7. The course of disease was 2-20 years. The concave regions were low (0.58 +/- 0.15) cm compared to surrounding normal skin, concave area (18.0 +/- 6.2) cm2. Cases in group A were treated with pure autologous free fat particle injection; cases in group B were treated with autologous free fat particle injection combined with bFGF (4,200 IU/10 mL). The clinical outcome were comparatively analyzed between two groups after operation.
The follow-up time was 6 to 24 months (mean, 12.5 months) in group A and 6 to 24 months (mean, 13 months) in group B. In group A, 6 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 50%; other 6 cases were required reinjection of fat particle 6-12 months postoperatively, of which two-time injections in 3 cases, three-time injections in 3 cases. In group B, 24 patients achieved satisfactory clinical effect after one injection of fat particle, the satisfactory rate of one therapy being 82.8%; only 5 cases were required reinjection one year postoperatively. There was statistically significant difference in the satisfactory rate of one injection between two groups (P < 0.05).
Autologous free fat particle grafting combined with bFGF to treat facial depression can acquire satisfactory clinical effect, which is a safe and effective method.
评价自体游离脂肪颗粒移植联合碱性成纤维细胞生长因子（bFGF）修复面部凹陷的效果。
2004年4月至2006年5月，将41例面部凹陷患者随机分为两组（A组和B组）。A组12例，于2004年4月至2004年12月收治。男5例，女7例，年龄16～49岁（平均31岁）。病因：先天性面部凹陷2例，半侧颜面萎缩2例，外伤性瘢痕5例，良性肿瘤切除术后3例。病程2～19年。凹陷区较周围正常皮肤低（0.52±0.13）cm，凹陷面积（16.0±5.3）cm²。B组29例，于2005年1月至2006年5月收治。男14例，女15例，年龄18～52岁（平均37岁）。病因：先天性面部凹陷3例，半侧颜面萎缩4例，外伤性瘢痕15例，良性肿瘤切除术后7例。病程2～20年。凹陷区较周围正常皮肤低（0.58±0.15）cm，凹陷面积（18.0±6.2）cm²。A组病例采用单纯自体游离脂肪颗粒注射治疗；B组病例采用自体游离脂肪颗粒注射联合bFGF（4200IU/10mL）治疗。术后对两组临床疗效进行对比分析。
A组随访时间6～24个月（平均12.5个月），B组随访时间6～24个月（平均13个月）。A组6例患者一次注射脂肪颗粒后临床效果满意，一次治疗满意率为50%；另6例患者术后6～12个月需再次注射脂肪颗粒，其中3例注射2次，3例注射3次。B组24例患者一次注射脂肪颗粒后临床效果满意，一次治疗满意率为82.8%；仅5例患者术后1年需再次注射。两组一次注射满意率比较，差异有统计学意义（P<0.05）。
自体游离脂肪颗粒移植联合bFGF治疗面部凹陷可获得满意的临床效果，是一种安全有效的方法。
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