同步放化疗后疾病进展或假性进展：神经肿瘤学中的陷阱
Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: pitfalls in neurooncology.
作者信息
Brandes Alba A, Tosoni Alicia, Spagnolli Federica, Frezza Giampiero, Leonardi Marco, Calbucci Fabio, Franceschi Enrico
机构信息
Department of Medical Oncology, Bellaria-Maggiore Hospital, AUSL Bologna, Bologna, Italy.
出版信息
Neuro Oncol. 2008 Jun;10(3):361-7. doi: 10.1215/15228517-2008-008. Epub 2008 Apr 9.
Abstract
Although radionecrosis has been exhaustively described in depth in the neurooncological literature, its diagnosis is still a challenging issue because its radiological pattern is frequently indistinguishable from that of tumor recurrence. This review discusses the causes of radionecrosis and the potential effect of adjuvant chemotherapy concomitant with radiotherapy on its rate and onset. The potential pitfalls in clinical studies attempting to make a differential diagnosis between radionecrosis and disease progression are also discussed.
摘要
尽管放射性坏死在神经肿瘤学文献中已有详尽深入的描述，但其诊断仍是一个具有挑战性的问题，因为其影像学表现常常与肿瘤复发难以区分。本综述讨论了放射性坏死的病因以及辅助化疗与放疗同时使用对其发生率和发病时间的潜在影响。还讨论了临床研究中在试图鉴别放射性坏死与疾病进展时可能存在的陷阱。
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