刺桐中异戊烯基黄酮的体外抗疟活性。

In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca.

作者信息

Khaomek Pranorm, Ichino Chikara, Ishiyama Aki, Sekiguchi Hitomi, Namatame Miyuki, Ruangrungsi Nijsiri, Saifah Ekarin, Kiyohara Hiroaki, Otoguro Kazuhiko, Omura Satoshi, Yamada Haruki

机构信息

Faculty of Science, Rangsit University, Pathumthani, 12000, Thailand.

出版信息

J Nat Med. 2008 Apr;62(2):217-20. doi: 10.1007/s11418-007-0214-z. Epub 2008 Jan 30.

DOI:10.1007/s11418-007-0214-z

PMID:18404327

Abstract

Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin (1), citflavanone (2), erythrisenegalone (3), lonchocarpol A (4), liquiritigenin (5), and 8-prenyldaidzein (6), were isolated from the extract. Diprenylated flavanone 4 showed a notable antimalarial activity (IC(50); 1.6 microg/mL); however 1 and 3 did not show the activity, even though these compounds possessed prenylated substitution.

摘要

刺桐茎皮的乙酸乙酯提取物对恶性疟原虫的多药耐药株（K1）显示出抗疟活性，从该提取物中分离出六种黄酮类化合物，羽扇豆叶素（1）、柑橘黄酮（2）、刺桐烯酮（3）、长荚豆醇A（4）、甘草素（5）和8-异戊烯基大豆苷元（6）。双异戊烯基黄酮4显示出显著的抗疟活性（IC50；1.6μg/mL）；然而，1和3没有显示出活性，尽管这些化合物具有异戊烯基取代。