一个Y染色体DNA片段在人类和黑猩猩中是保守的。

A Y-chromosomal DNA fragment is conserved in human and chimpanzee.

作者信息

Rasheed B K, Whisenant E C, Fernandez R, Ostrer H, Bhatnagar Y M

机构信息

Department of Structural and Cellular Biology, University of South Alabama, Mobile 36688.

出版信息

Mol Biol Evol. 1991 Jul;8(4):416-32. doi: 10.1093/oxfordjournals.molbev.a040663.

DOI:10.1093/oxfordjournals.molbev.a040663

PMID:1840631

Abstract

A human male-specific Y-chromosomal DNA fragment (lambda YH2D6) has been isolated. By deletion-mapping analysis, 2D6 has been localized to the euchromatic portion of the long arm (Yq11) of the human Y chromosome. Among great apes, this fragment was found to be conserved in male chimpanzee but was lacking in male gorilla and male orangutan. No homologous fragments were detected in females of orangutan, gorilla, chimpanzee, or human. Nucleotide sequence analysis indicated the presence of partial-Alu-elements and of sequences similar to the GATA repeats of the snake Bkm sequence.

摘要

已分离出一种人类男性特异性Y染色体DNA片段（λYH2D6）。通过缺失图谱分析，2D6已定位到人类Y染色体长臂（Yq11）的常染色质部分。在大猩猩中，发现该片段在雄性黑猩猩中保守，但在雄性大猩猩和雄性猩猩中缺失。在猩猩、大猩猩、黑猩猩或人类的雌性中未检测到同源片段。核苷酸序列分析表明存在部分Alu元件以及与蛇Bkm序列的GATA重复序列相似的序列。