成骨细胞：分化与转分化

Osteoblastic cells: differentiation and trans-differentiation.

作者信息

Kassem Moustapha, Abdallah Basem M, Saeed Hamid

机构信息

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital & Medical Biotechnology Centre, University of Southern Denmark.

出版信息

Arch Biochem Biophys. 2008 May 15;473(2):183-7. doi: 10.1016/j.abb.2008.03.028. Epub 2008 Mar 29.

DOI:10.1016/j.abb.2008.03.028

PMID:18406334

Abstract

The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

摘要

成骨细胞是形成骨骼的细胞，来源于存在于骨髓基质中的间充质干细胞（MSC）。MSC能够多谱系分化为中胚层类型的细胞，如成骨细胞和脂肪细胞。了解MSC向成骨细胞分化的潜在机制是骨生物学的核心课题，这可以为骨维持机制提供见解，也能为增加成骨细胞分化从而促进骨形成提供新的药理学靶点。