识别记忆与前额叶皮层：使用重复经颅磁刺激区分回忆和熟悉过程
Recognition memory and prefrontal cortex: dissociating recollection and familiarity processes using rTMS.
作者信息
Turriziani Patrizia, Oliveri Massimiliano, Salerno Silvia, Costanzo Floriana, Koch Giacomo, Caltagirone Carlo, Carlesimo Giovanni Augusto
机构信息
Dipartimento di Psicologia, Università di Palermo, Palermo, Italy.
出版信息
Behav Neurol. 2008;19(1-2):23-7. doi: 10.1155/2008/568057.
Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recognition memory based on familiarity as well as recollection.
认知记忆可以通过对项目熟悉程度的评估以及对遇到项目的背景的回忆来支持。这些记忆过程的神经基质存在争议。为了解决这些问题，我们对执行记忆/知晓任务的健康受试者的右侧和左侧背外侧前额叶皮层（DLPFC）施加重复经颅磁刺激（rTMS）。当在左右DLPFC上对刺激进行编码之前施加rTMS时，会破坏熟悉度判断。当在右侧DLPFC上对刺激进行编码之前施加rTMS时，会破坏回忆。这些发现表明，DLPFC在基于熟悉度和回忆的认知记忆中起关键作用。
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