Nouri-Majalan Nader, Moghimi Mansour
Nephrology Department, Sadoughi Medical University, Yazd, Iran.
J Med Case Rep. 2008 Apr 19;2:112. doi: 10.1186/1752-1947-2-112.
Cutaneous mucormycosis is a rare entity related to kidney transplantation. It usually presents with ecthyma-like lesions and black necrotic cellulitis. We report an unusual case of primary cutaneous mucormycosis presenting as erythema-nodosum-like lesions in a woman who had received a renal transplant.
A 49-year-old woman with diabetes received a living-unrelated kidney transplant. Her clinical course was uneventful for the first six months after transplantation. She then developed multiple, painful, erythema-nodosum-like lesions on her right leg and thigh following an episode of minor trauma. Mucormycosis was diagnosed by skin biopsy. Microscopic examination also showed panniculitis. The patient was treated successfully with amphotericin B and surgical resection. To our knowledge, this is the first description of primary cutaneous mucormycosis with erythema-nodosum-like lesions and panniculitis after renal transplantation.
Cutaneous mucormycosis should be considered in the differential diagnosis when a kidney transplant recipient develops erythema-nodosum-like lesions with panniculitis.
皮肤毛霉病是一种与肾移植相关的罕见疾病。它通常表现为深脓疱样病变和黑色坏死性蜂窝织炎。我们报告一例不寻常的原发性皮肤毛霉病,表现为红斑结节样病变,发生在一名接受肾移植的女性患者身上。
一名49岁的糖尿病女性接受了非亲属活体肾移植。移植后的前六个月她的临床过程平稳。之后,在一次轻微外伤后,她的右腿和大腿出现了多个疼痛的红斑结节样病变。通过皮肤活检诊断为毛霉病。显微镜检查还显示了脂膜炎。患者接受两性霉素B治疗和手术切除后成功治愈。据我们所知,这是肾移植后原发性皮肤毛霉病伴红斑结节样病变和脂膜炎的首次描述。
当肾移植受者出现伴有脂膜炎的红斑结节样病变时,在鉴别诊断中应考虑皮肤毛霉病。