Nasser N J
Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel.
Cell Mol Life Sci. 2008 Jun;65(11):1706-15. doi: 10.1007/s00018-008-7584-6.
Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy.
乙酰肝素酶是一种内切糖苷酶,可降解细胞表面和细胞外基质上的硫酸乙酰肝素。乙酰肝素酶的生理功能包括硫酸乙酰肝素周转、胚胎发育、毛发生长和伤口愈合。乙酰肝素酶与多种病理状况有关,如肿瘤生长、血管生成、转移、炎症和肾小球疾病。多种恶性肿瘤中乙酰肝素酶的过表达表明它可能成为抗癌治疗的靶点。