大麻素1型受体：脂肪细胞的又一利器。
Cannabinoid type 1 receptor: another arrow in the adipocytes' bow.
作者信息
Bellocchio L, Cervino C, Vicennati V, Pasquali R, Pagotto U
机构信息
Center of Applied Biomedical Research (CRBA), Department of Internal Medicine and Gastroenterology, S.Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy.
出版信息
J Neuroendocrinol. 2008 May;20 Suppl 1:130-8. doi: 10.1111/j.1365-2826.2008.01682.x.
The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue, including cell proliferation, differentiation and secretion. Here, we will review the effects of cannabinoid type 1 (CB(1)) receptor activation/blockade in adipocytes by summarising the data in the literature since the discovery of the presence of this receptor in adipose tissue. We will also discuss our original data obtained in mouse 3T3-L1 adipocyte cells using WIN55 212, a CB(1)/CB(2) receptor agonist and SR141716 (rimonabant), a specific CB(1) receptor antagonist, respectively, in different experimental settings.
内源性大麻素系统最近已成为脂肪组织多种功能的重要调节因子，包括细胞增殖、分化和分泌。在此，我们将通过总结自脂肪组织中发现该受体以来的文献数据，综述1型大麻素（CB(1)）受体激活/阻断对脂肪细胞的影响。我们还将讨论在不同实验环境下，分别使用CB(1)/CB(2)受体激动剂WIN55 212和特异性CB(1)受体拮抗剂SR141716（利莫那班），在小鼠3T3-L1脂肪细胞中获得的原始数据。
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