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动力囊内扁桃体切除术和腺样体切除术的疗效

Efficacy of powered intracapsular tonsillectomy and adenoidectomy.

作者信息

Tunkel David E, Hotchkiss Karin S, Carson Kathryn A, Sterni Laura M

机构信息

Departments of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA.

出版信息

Laryngoscope. 2008 Jul;118(7):1295-302. doi: 10.1097/MLG.0b013e3181724269.

Abstract

OBJECTIVES/HYPOTHESIS: We sought to determine the effectiveness of powered intracapsular tonsillectomy and adenoidectomy (PITA) in the treatment of children with moderately severe obstructive sleep apnea and to measure changes in quality of life that occur with such treatment.

STUDY DESIGN

Prospective, nonrandomized clinical trial in an academic pediatric otolaryngology practice.

METHODS

Convenience sample of children ages 3 to 12 years diagnosed with obstructive sleep apnea of moderate severity, defined as an apnea-hypopnea index (AHI) between 5 and 20 on polysomnography. Children with recurrent streptococcal pharyngitis, chromosomal abnormalities, craniofacial abnormalities, neuromotor disease, sickle cell disease, obesity, or coagulopathy were excluded. PITA was performed by using the microdebrider. Polysomnography was performed before surgery and repeated 4 to 8 weeks after surgery. The Obstructive Sleep Apnea (OSA)-18 questionnaire was completed at surgery and at the time of postoperative polysomnography to assess quality of life changes. The main outcome measure was cure of obstructive sleep apnea, as defined by a postoperative AHI of 1 or less for complete cure and less than 5 for partial cure. Improvements in quality of life were assessed by changes in the OSA-18 questionnaire.

RESULTS

Nineteen children underwent PITA for moderate obstructive sleep apnea syndrome (OSAS), and 14 completed postoperative polysomnography. All 14 subjects who completed the study achieved at least partial cure. Thirteen of 14 (93%) subjects had a complete cure of OSAS after PITA. The median preoperative AHI was 7.9, and the median AHI after surgery was 0.1. The mean number of arousals per hour before surgery was 9.5, and this was reduced to a mean of 5.6 after surgery. Quality of life measures on OSA-18 also improved, with large improvements in total quality of life scores and in all five domains seen after surgery.

CONCLUSIONS

PITA cures otherwise healthy children with obstructive sleep apnea of moderate severity, at least in the short-term, as documented by postoperative polysomnography. Improvements in quality of life measures, as documented by changes in OSA-18, were seen in all children as well.

摘要

目的/假设:我们试图确定动力囊内扁桃体切除术和腺样体切除术(PITA)治疗中度严重阻塞性睡眠呼吸暂停儿童的有效性,并衡量这种治疗所带来的生活质量变化。

研究设计

在一家学术性儿科耳鼻喉科诊所进行的前瞻性、非随机临床试验。

方法

选取3至12岁被诊断为中度阻塞性睡眠呼吸暂停的儿童作为便利样本,中度阻塞性睡眠呼吸暂停定义为多导睡眠图检查时呼吸暂停低通气指数(AHI)在5至20之间。排除患有复发性链球菌性咽炎、染色体异常、颅面异常、神经运动疾病、镰状细胞病、肥胖或凝血障碍的儿童。使用微型清创器进行PITA手术。在手术前进行多导睡眠图检查,并在术后4至8周重复检查。在手术时和术后多导睡眠图检查时完成阻塞性睡眠呼吸暂停(OSA)-18问卷,以评估生活质量变化。主要结局指标是阻塞性睡眠呼吸暂停的治愈情况,完全治愈定义为术后AHI为1或更低,部分治愈定义为术后AHI小于5。通过OSA-18问卷的变化评估生活质量的改善情况。

结果

19名儿童因中度阻塞性睡眠呼吸暂停综合征(OSAS)接受了PITA手术,14名儿童完成了术后多导睡眠图检查。所有14名完成研究的受试者至少实现了部分治愈。14名受试者中有13名(93%)在PITA手术后实现了OSAS的完全治愈。术前AHI中位数为7.9,术后AHI中位数为0.1。术前每小时平均觉醒次数为9.5次,术后降至平均5.6次。OSA-18的生活质量指标也有所改善,术后生活质量总分及所有五个领域均有大幅改善。

结论

PITA可治愈其他方面健康的中度严重阻塞性睡眠呼吸暂停儿童,至少在短期内如此,术后多导睡眠图检查证明了这一点。所有儿童的生活质量指标也有所改善,OSA-18的变化证明了这一点。

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