3,5-二氨基哌啶翻译抑制剂在血清中的抗菌活性。
Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.
作者信息
Zhou Yuefen, Chow Chun, Murphy Douglas E, Sun Zhongxiang, Bertolini Thomas, Froelich Jamie M, Webber Stephen E, Hermann Thomas, Wall Daniel
机构信息
Anadys Pharmaceuticals, Inc., San Diego, USA.
出版信息
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3369-75. doi: 10.1016/j.bmcl.2008.04.023. Epub 2008 Apr 13.
Abstract
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.
摘要
3,5-二氨基哌啶系列的翻译抑制剂作为氨基糖苷类似物发挥作用，可抑制细菌生长。在此我们展示了在有血清和无血清情况下的抗菌构效关系，特别关注铜绿假单胞菌。
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Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1206-10. doi: 10.1016/j.bmcl.2006.12.024. Epub 2006 Dec 12.
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