精神分裂症患者及其亲属的语用语言和心理理论缺陷
Pragmatic language and theory of mind deficits in people with schizophrenia and their relatives.
作者信息
Mazza Monica, Di Michele Vittorio, Pollice Rocco, Casacchia Massimo, Roncone Rita
机构信息
Department of Psychiatry, University of L'Aquila, L'Aquila, Italy.
出版信息
Psychopathology. 2008;41(4):254-63. doi: 10.1159/000128324. Epub 2008 Apr 26.
BACKGROUND
Deficits in theory of mind have frequently been observed in people affected by illnesses characterized by disrupted social behaviour like autism and psychoses. In schizophrenia, a pragmatic deficit in expressive language can also be observed. The present study was designed in order to assess the suitability of theory of mind and pragmatic conversation abilities as possible cognitive endophenotypes of schizophrenia.
METHODS
First- and second-order false belief tasks and pragmatic deficits in expressive language were examined in 38 patients with schizophrenia, in 34 non-psychotic relatives and in 44 healthy controls. An extensive clinical and neuropsychological assessment was also conducted.
RESULTS
Schizophrenic people and their first-degree relatives performedworse than the normal control subjects in false belief and pragmatic conversation tasks. General cognitive ability and neuropsychological measures of executive functions were not related to social cognition tasks.
CONCLUSIONS
Theory of mind disorders and failing to understand the gricean conversational maxims are associated with schizophrenia liability.
背景
在患有以社交行为紊乱为特征的疾病（如自闭症和精神病）的人群中，经常观察到心理理论缺陷。在精神分裂症中，也可观察到表达性语言的语用缺陷。本研究旨在评估心理理论和语用对话能力作为精神分裂症可能的认知内表型的适用性。
方法
对38例精神分裂症患者、34例非精神病性亲属和44例健康对照者进行了一阶和二阶错误信念任务以及表达性语言的语用缺陷检查。还进行了广泛的临床和神经心理学评估。
结果
精神分裂症患者及其一级亲属在错误信念和语用对话任务中的表现比正常对照受试者差。一般认知能力和执行功能的神经心理学测量与社会认知任务无关。
结论
心理理论障碍和未能理解格赖斯会话准则与精神分裂症易感性相关。
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