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竞争对辅助生殖技术结局的影响。

The effects of competition on assisted reproductive technology outcomes.

机构信息

Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC 20307, USA.

出版信息

Fertil Steril. 2010 Apr;93(6):1820-30. doi: 10.1016/j.fertnstert.2008.02.159. Epub 2008 Apr 28.

Abstract

OBJECTIVE

To evaluate the relationship between competition among fertility clinics and assisted reproductive technology (ART) treatment outcomes, particularly multiple births.

DESIGN

Using clinic-level data from 1995 to 2001, we examined the relationship between competition and clinic-level ART outcomes and practice patterns.

SETTING

National database registry.

PATIENT(S): Clinics performing ART.

INTERVENTION(S): The number of clinics within a 20-mile (32.19-km) radius of a given clinic.

MAIN OUTCOME MEASURE(S): Clinic-level births, singleton births, and multiple births per ART cycle; multiple births per ART birth; average number of embryos transferred per cycle; and the proportion of cycles for women under age 35 years.

RESULT(S): The number of competing clinics is not strongly associated with ART birth and multiple birth rates. Relative to clinics with no competitors, the rate of multiple births per cycle is lower (-0.03 percentage points) only for clinics with more than 15 competitors. Embryo transfer practices are not statistically significantly associated with the number of competitors. Clinic-level competition is strongly associated with patient mix. The proportion of cycles for patients under 35 years old is 6.4 percentage points lower for clinics with more than 15 competitors than for those with no competitors.

CONCLUSION(S): Competition among fertility clinics does not appear to increase rates of multiple births from ART by promoting more aggressive embryo transfer decisions.

摘要

目的

评估生育诊所之间的竞争与辅助生殖技术(ART)治疗结果之间的关系,特别是多胎妊娠。

设计

利用 1995 年至 2001 年的诊所水平数据,我们研究了竞争与诊所水平的 ART 结果和实践模式之间的关系。

设置

国家数据库注册。

患者

进行 ART 的诊所。

干预措施

给定诊所 20 英里(32.19 公里)半径内的诊所数量。

主要观察指标

每个 ART 周期的诊所出生人数、单胎出生人数和多胎出生人数;每个 ART 出生的多胎出生人数;每个周期平均转移的胚胎数量;以及 35 岁以下妇女的周期比例。

结果

竞争诊所的数量与 ART 出生率和多胎出生率没有密切关联。与没有竞争的诊所相比,只有当竞争诊所超过 15 家时,每个周期的多胎出生率才会降低(低 0.03 个百分点)。胚胎移植实践与竞争数量没有统计学上的显著关联。诊所级别的竞争与患者构成密切相关。有 15 家以上竞争诊所的患者中,35 岁以下患者的周期比例比没有竞争的诊所低 6.4 个百分点。

结论

生育诊所之间的竞争似乎并没有通过促进更积极的胚胎移植决策来增加 ART 的多胎妊娠率。

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