大脑发育与退化过程中的细胞死亡：半胱天冬酶表达的调控可能是关键！ - Suppr

Cell death in brain development and degeneration: control of caspase expression may be key!

作者信息

Madden Shane D, Cotter Thomas G

机构信息

Cell Development and Disease Laboratory, Department of Biochemistry, Biosciences Institute, University College, Cork, Ireland.

出版信息

Mol Neurobiol. 2008 Feb;37(1):1-6. doi: 10.1007/s12035-008-8021-4. Epub 2008 May 1.

DOI:10.1007/s12035-008-8021-4

PMID:18449809

Abstract

摘要

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Cell death in brain development and degeneration: control of caspase expression may be key!大脑发育与退化过程中的细胞死亡：半胱天冬酶表达的调控可能是关键！

Mol Neurobiol. 2008 Feb;37(1):1-6. doi: 10.1007/s12035-008-8021-4. Epub 2008 May 1.

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.半胱天冬酶-4参与内质网应激诱导的细胞凋亡及β淀粉样蛋白诱导的细胞死亡。

J Cell Biol. 2004 May 10;165(3):347-56. doi: 10.1083/jcb.200310015. Epub 2004 May 3.

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Pathogenesis of hippocampal neuronal death after hypoxia-ischemia changes during brain development.缺氧缺血后海马神经元死亡的发病机制在脑发育过程中会发生变化。

Neuroscience. 2004;127(1):113-23. doi: 10.1016/j.neuroscience.2004.03.062.

Treating neurodegenerative conditions through the understanding of neuronal apoptosis.通过了解神经元凋亡来治疗神经退行性疾病。

Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):3-23. doi: 10.2174/1568007053005118.

Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis.肌萎缩侧索硬化症小鼠模型中半胱天冬酶与其抑制剂之间的失衡

Brain Res. 2007 May 7;1148:234-42. doi: 10.1016/j.brainres.2007.02.087. Epub 2007 Mar 7.

Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor.

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Caspase pathways, neuronal apoptosis, and CNS injury.半胱天冬酶通路、神经元凋亡与中枢神经系统损伤。

J Neurotrauma. 2000 Oct;17(10):811-29. doi: 10.1089/neu.2000.17.811.

Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain.未成熟大鼠脑兴奋性毒性损伤后神经元和胶质细胞中半胱天冬酶途径的不同时空激活。

J Neurosci Res. 2007 Dec;85(16):3545-56. doi: 10.1002/jnr.21450.

Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.神经元型一氧化氮合酶抑制对新生仔猪大脑皮层缺氧时半胱天冬酶-9活性的影响。

Neurosci Lett. 2006 Jun 19;401(1-2):81-5. doi: 10.1016/j.neulet.2006.02.070. Epub 2006 Mar 20.

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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis.细胞凋亡蛋白酶综述：生物活性和细胞凋亡的关键调节剂。

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Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases.抗氧化酶的基因传递抑制人类免疫缺陷病毒 1 型 gp120 诱导的胱天蛋白酶表达。

Neuroscience. 2012 Jul 12;214:68-77. doi: 10.1016/j.neuroscience.2012.03.061. Epub 2012 Apr 21.

Immunoelectron microscopic and biochemical studies of caspase-cleaved tau in a mouse model of tauopathy.免疫电镜和生物化学研究在 tau 病小鼠模型中 caspase 切割的 tau。

J Neuropathol Exp Neurol. 2011 Sep;70(9):779-87. doi: 10.1097/NEN.0b013e31822ac9c9.

Apoptotic and non-apoptotic caspase functions in neural development.凋亡和非凋亡 Caspase 在神经发育中的功能。

Neurochem Res. 2011 Jul;36(7):1253-60. doi: 10.1007/s11064-010-0341-x. Epub 2010 Dec 7.

本文引用的文献

Cell deaths in normal vertebrate ontogeny.正常脊椎动物个体发育中的细胞死亡。

Biol Rev Camb Philos Soc. 1951 Feb;26(1):59-86. doi: 10.1111/j.1469-185x.1951.tb00774.x.

Calpains and human disease.钙蛋白酶与人类疾病。

Subcell Biochem. 2007;45:29-53. doi: 10.1007/978-1-4020-6191-2_2.

Key apoptosis regulating proteins are down-regulated during postnatal tissue development.关键的细胞凋亡调节蛋白在出生后组织发育过程中下调。

Int J Dev Biol. 2007;51(5):415-23. doi: 10.1387/ijdb.062263sm.

Endoplasmic reticulum stress: signaling the unfolded protein response.内质网应激：未折叠蛋白反应的信号传导

Physiology (Bethesda). 2007 Jun;22:193-201. doi: 10.1152/physiol.00050.2006.

Lysosomal cysteine cathepsins: signaling pathways in apoptosis.溶酶体半胱氨酸组织蛋白酶：细胞凋亡中的信号通路

Biol Chem. 2007 Jun;388(6):555-60. doi: 10.1515/BC.2007.064.

Cell death in the nervous system.神经系统中的细胞死亡。

Nature. 2006 Oct 19;443(7113):796-802. doi: 10.1038/nature05293.

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.半胱天冬酶-9对溶酶体细胞死亡途径的非凋亡小体依赖性激活。

Mol Cell Biol. 2006 Nov;26(21):7880-91. doi: 10.1128/MCB.00716-06. Epub 2006 Sep 11.

Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina.组蛋白脱乙酰酶活性调节发育中小鼠视网膜中apaf-1和半胱天冬酶3的表达。

Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2765-72. doi: 10.1167/iovs.05-1383.

BCL-2 in the crosshairs: tipping the balance of life and death.BCL-2 成为众矢之的：扭转生死平衡。

Cell Death Differ. 2006 Aug;13(8):1339-50. doi: 10.1038/sj.cdd.4401992. Epub 2006 Jun 9.

Mitochondrial membrane permeability transition and cell death.线粒体膜通透性转换与细胞死亡。

Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1297-300. doi: 10.1016/j.bbabio.2006.03.017. Epub 2006 Apr 19.

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Cell death in brain development and degeneration: control of caspase expression may be key!

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