MC4R基因附近的常见基因变异与腰围和胰岛素抵抗有关。
Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
作者信息
Chambers John C, Elliott Paul, Zabaneh Delilah, Zhang Weihua, Li Yun, Froguel Philippe, Balding David, Scott James, Kooner Jaspal S
机构信息
Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl., London W2 1PG, UK.
出版信息
Nat Genet. 2008 Jun;40(6):716-8. doi: 10.1038/ng.156. Epub 2008 May 4.
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
我们对2684名印度裔亚洲人进行了一项全基因组关联研究（318,237个单核苷酸多态性），以研究胰岛素抵抗及相关表型，并在另外11,955名印度裔亚洲人或欧洲裔个体中进行了进一步检测。我们发现，MC4R附近的rs12970134与腰围相关（P = 1.7 x 10(-9)），且独立地与胰岛素抵抗相关。rs12970134风险等位基因的纯合子腰围大约增加2厘米。MC4R附近的常见基因变异与肥胖和胰岛素抵抗风险相关。
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