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[干细胞支架在再生医学中的重要贡献、必要性及治疗应用]

[Important contribution and necessity of stem cells scaffolds for regenerative medicine and the therapeutic applications].

作者信息

Tabata Yasuhiko

机构信息

Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University.

出版信息

Nihon Rinsho. 2008 May;66(5):881-6.

Abstract

For successful regeneration therapy of tissues and organs, it is important and indispensable to develop the technology and methodology of tissue engineering with biomaterials for molecular design and creation of a local environment which enables stem cells to enhance the proliferation and differentiation, inducing cell-based tissue regeneration. Various scaffolds of biomaterials have been investigated to demonstrate the feasibility in the basic researches of stem cell biology and the applications of their results to regenerative therapy. This paper introduces several examples of regenerative medical therapy based on tissue engineering technologies to emphasize the scientifically and clinically significant contribution of cell scaffolds not only to the regenerative medicine of basic stem cell researches, but also to their therapeutic applications of regenerative medicine.

摘要

对于组织和器官的成功再生治疗而言,开发用于分子设计的生物材料组织工程技术和方法,并创建能够促进干细胞增殖和分化、诱导基于细胞的组织再生的局部环境,是至关重要且不可或缺的。人们已经研究了各种生物材料支架,以证明其在干细胞生物学基础研究中的可行性,以及将研究成果应用于再生治疗的可行性。本文介绍了基于组织工程技术的再生医学治疗的几个实例,以强调细胞支架不仅对基础干细胞研究的再生医学,而且对再生医学的治疗应用所做出的具有科学和临床意义的贡献。

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