额外的中心体和/或染色体会延长人类细胞的有丝分裂。
Extra centrosomes and/or chromosomes prolong mitosis in human cells.
作者信息
Yang Zhenye, Loncarek Jadranka, Khodjakov Alexey, Rieder Conly L
机构信息
Division of Molecular Medicine, Wadsworth Center, N.Y.S. Department of Health, Empire State Plaza, Albany, New York 12201-0509, USA.
出版信息
Nat Cell Biol. 2008 Jun;10(6):748-51. doi: 10.1038/ncb1738. Epub 2008 May 11.
Abstract
Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We found that doubling the chromosome number added approximately 10 min to a 20 min division, whereas doubling the number of centrosomes added approximately 30 min more. Extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non-genetic means and extra chromosomes and centrosomes probably contribute to the elevated mitotic index seen in many tumours.
摘要
我们利用激光显微手术和细胞融合技术，探究了额外的中心体和/或染色体如何影响人类细胞有丝分裂的持续时间。我们发现，将染色体数量加倍会使原本20分钟的分裂时间增加约10分钟，而将中心体数量加倍则会使分裂时间再增加约30分钟。额外的中心体和/或染色体通过延迟纺锤体组装检查点的满足来延长有丝分裂。因此，有丝分裂可以通过非遗传方式延长，额外的染色体和中心体可能导致了许多肿瘤中观察到的有丝分裂指数升高。
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