Junker Johan P E, Kratz Camilla, Tollbäck Anna, Kratz Gunnar
Department of Plastic Surgery, University Hospital, Linköping, Sweden.
Burns. 2008 Nov;34(7):942-6. doi: 10.1016/j.burns.2008.01.010. Epub 2008 May 8.
Scar formation as a result of burn wounds leads to contraction of the formed granulation tissue, which causes both aesthetic and functional impairment for the patient. Currently, the main treatment methods focus on stretching to prevent tissue contraction. The myofibroblasts play a key role in the contraction of granulation tissue during scar formation, but their presence should normally decrease after wound re-epithelialization. In hypertrophic scars the myofibroblasts persist and is believed to cause further hypertrophy. Previous studies have shown that mechanical tension leads to increased myofibroblast numbers in granulation tissue. In order to evaluate the effect mechanical tension as a result of stretching has on the number of myofibroblasts in burn wound scars, an in vitro model was used. This model used human burn scar biopsies which were stretched and examined after 1 and 6 days to evaluate the effect on the number of myofibroblasts. The stretching caused an increase in the number of myofibroblasts after mechanical stimulation. This indicates that mechanical stimulation using stretching induces fibroblast to myofibroblast transdifferentiation, thus underlining the importance of further investigations of optimal methods of this regime for treating burn scars.
烧伤创面形成的瘢痕会导致新生肉芽组织收缩，给患者造成美观和功能上的损害。目前，主要的治疗方法集中在拉伸以防止组织收缩。肌成纤维细胞在瘢痕形成过程中肉芽组织的收缩中起关键作用，但在伤口重新上皮化后其数量通常应会减少。在增生性瘢痕中，肌成纤维细胞持续存在，并被认为会导致进一步的增生。先前的研究表明，机械张力会导致肉芽组织中肌成纤维细胞数量增加。为了评估拉伸产生的机械张力对烧伤创面瘢痕中肌成纤维细胞数量的影响，使用了一种体外模型。该模型采用人烧伤瘢痕活检组织，在拉伸1天和6天后进行检查，以评估对肌成纤维细胞数量的影响。机械刺激后，拉伸导致肌成纤维细胞数量增加。这表明使用拉伸的机械刺激会诱导成纤维细胞向肌成纤维细胞转分化，从而凸显了进一步研究该治疗方案的最佳方法以治疗烧伤瘢痕的重要性。
