Department of Neurosurgery University of Groningen The Netherlands.
Mediators Inflamm. 1994;3(3):177-80. doi: 10.1155/S0962935194000232.
Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum.
脂皮质蛋白-1、脂皮质蛋白-2 和脂皮质蛋白-5 在大鼠中进行了免疫组织化学评估。除了未接受治疗的动物外,其他动物还接受了甲泼尼龙或 21-氨基甾醇 U-74389F 的预处理。在未用类固醇预处理的动物中,除了散在的小胶质细胞和脉络丛外,大部分脑组织中没有脂皮质蛋白免疫反应,但在类固醇预处理的动物中,实质成分有明显的免疫染色。在类固醇预处理的动物中,脑组织中脂皮质蛋白的免疫反应可能表明在进入组织的类固醇的影响下,局部形成了脂皮质蛋白。显示免疫染色的细胞成分包括脑膜细胞、神经元、室管膜、少突胶质细胞和毛细血管内皮细胞。