[The association study of the DRD2 gene C939T polymorphism and schizophrenia.].
作者信息
Monakhov M V, Golimbet V E, Chubabriia K V, Zykov V V, Kovtun A L, Karpov V L
机构信息
Institut molekuliarnoĭ biologii im. V.A. Engel'gardta, Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bol'nitsa #1 im. N.A. Alekseeva, Moskva; Viatskiĭ gosudarstvennyĭ universitet, Kirov.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(10):58-60.
Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 capital ES, Cyrillic939capital TE, Cyrillic (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (c2=7,2; small er, Cyrillic=0,007; OR=1,96, 95% CI=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.
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