Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.

OBJECTIVE

Activation of coagulation and inflammation are parts of the innate host response to infection that may contribute to organ dysfunction and death when control of these systems is compromised. Thus, functional single nucleotide polymorphisms within candidate genes of the inflammation and coagulation cascade are possible factors which may influence severity and/or mortality in acute respiratory distress syndrome. The aim of this study was to investigate whether the factor V Leiden mutation (Arg506Gln) is associated with altered severity and/or mortality in acute respiratory distress syndrome.

DESIGN

Retrospective cohort, genetic association study.

SETTING

Tertiary care intensive care unit.

PATIENTS

Adults (white Germans) with acute respiratory distress syndrome (n = 106).

INTERVENTIONS

Genotyping for the factor V Leiden mutation.

MEASUREMENTS AND MAIN RESULTS

Using Kaplan-Meier estimates to compare outcome, 30-day survival was significantly associated with the factor V Leiden mutation (p = .049). Thirty-day survival rates were 100% for Arg/Gln (n = 7) genotypes but only 58% for Arg/Arg (n = 99) genotypes, respectively.

CONCLUSION

We show for the first time that a heterozygous factor V Leiden genotype is associated with improved 30-day survival in patients with acute respiratory distress syndrome.