Kapiloff M S, Mathis J M, Nelson C A, Lin C R, Rosenfeld M G
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093-0648.
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3710-4. doi: 10.1073/pnas.88.9.3710.
Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.
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