Axelrod Yekaterina K, Diringer Michael N
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005.
Temperature management in acute neurologic disorders has received considerable attention in the last 2 decades. Numerous trials of hypothermia have been performed in patients with head injury, stroke, and cardiac arrest. This article reviews the physiology of thermoregulation and mechanisms responsible for hyperpyrexia. Detrimental effects of fever and benefits of normalizing elevated temperature in experimental models are discussed. This article presents a detailed analysis of trials of induced hypothermia in patients with acute neurologic insults and describes methods of fever control.
在过去20年中，急性神经系统疾病的体温管理受到了相当多的关注。针对头部受伤、中风和心脏骤停患者进行了大量低温治疗试验。本文回顾了体温调节的生理学以及导致高热的机制。讨论了发热在实验模型中的有害影响以及将升高的体温恢复正常的益处。本文对急性神经损伤患者诱导低温治疗试验进行了详细分析，并描述了控制发热的方法。
