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影响晚期癌症患者的临床因素的描述性分析。

Descriptive analysis of clinical factors affecting terminally ill cancer patients.

作者信息

Jiménez-Gordo A M, Feliu J, Martínez B, de-Castro J, Rodríguez-Salas N, Sastre N, Vilches Y, Espinosa E, Rodríguez-Aizcorbe J R, González-Barón M

机构信息

Medical Oncology, University Hospital Getafe, Avenida de la Ermita, n 2, Portal M, 2 B, Alcobendas, 28108 Madrid, Spain.

出版信息

Support Care Cancer. 2009 Mar;17(3):261-9. doi: 10.1007/s00520-008-0460-y. Epub 2008 Jun 5.

Abstract

GOALS OF WORK

To make a descriptive analysis of clinical and laboratories parameters in advanced neoplastic patients.

MATERIALS AND METHODS

We interviewed 406 terminally ill cancer patients to study demographic and neoplastic data, 24 graded symptoms, 21 analytical parameters and scales to evaluate general condition, quality of life and independence in daily activities.

MAIN RESULTS

An average of 9.3 symptoms per patient were detected and median survival was 26.5 days. Most frequent symptoms were asthenia (96.8%), anorexia (94.8%), weight loss (88.1%) and pain (80.5%). Principal laboratory abnormalities were high blood sedimentation rate (96%), high cytolysis and cholestasis enzyme levels (50-77%), anemia (81.5%), low protein (66%) and low albumin levels (67%). Symptom prevalence was different according to age, gender, primary tumour, location of metastasis, laboratory parameters, performance status, quality of life or independence in daily-living activities.

CONCLUSIONS

We should know more frequent symptoms affecting terminal cancer patients and any factor contributing to it to provide more comfort in the final phases of life.

摘要

工作目标

对晚期肿瘤患者的临床和实验室参数进行描述性分析。

材料与方法

我们采访了406名晚期癌症患者,以研究人口统计学和肿瘤学数据、24种分级症状、21项分析参数以及用于评估一般状况、生活质量和日常生活独立性的量表。

主要结果

每位患者平均检测到9.3种症状,中位生存期为26.5天。最常见的症状是乏力(96.8%)、厌食(94.8%)、体重减轻(88.1%)和疼痛(80.5%)。主要的实验室异常包括血沉率升高(96%)、细胞溶解和胆汁淤积酶水平升高(50 - 77%)、贫血(81.5%)、低蛋白(66%)和低白蛋白水平(67%)。症状患病率因年龄、性别、原发肿瘤、转移部位、实验室参数、体能状态、生活质量或日常生活活动独立性而异。

结论

我们应该了解影响晚期癌症患者的更常见症状以及任何促成因素,以便在生命的最后阶段提供更多舒适感。

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