自身免疫性肝炎的临床特征与管理
Clinical features and management of autoimmune hepatitis.
作者信息
Krawitt Edward-L
机构信息
Department of Medicine, University of Vermont, Given C-246 Burlington, Vermont 05405-0068, USA.
出版信息
World J Gastroenterol. 2008 Jun 7;14(21):3301-5. doi: 10.3748/wjg.14.3301.
Abstract
Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology which can progress to cirrhosis. Its clinical manifestations are highly variable and sometimes follow a fluctuating course. Diagnosis is based on characteristic histologic, clinical, biochemical and serological findings. Anti-inflammatory/immunosuppressive treatment frequently induces remission but long-term maintenance therapy is often required. Liver transplantation is generally successful in patients with decompensated cirrhosis unresponsive to or intolerant of medical therapy.
摘要
自身免疫性肝炎（AIH）是一种病因不明的慢性肝炎，可进展为肝硬化。其临床表现高度多变，有时呈波动病程。诊断基于特征性的组织学、临床、生化和血清学表现。抗炎/免疫抑制治疗常可诱导缓解，但往往需要长期维持治疗。对于药物治疗无反应或不耐受的失代偿期肝硬化患者，肝移植通常是成功的。
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